| icon | info | type |
|---|---|---|
 | Platinum Obtain all trophies |  Platinum |
 | Isaac's Tears Kill Isaac with Isaac |  Bronze |
 | Mom's Knife Kill Satan with Isaac | Bronze |
 | Isaac's Heart Kill Isaac with The Lost | Bronze |
 | The Mind Kill Satan with The Lost | Bronze |
 | Magdalene Have 7 or more max red hearts at one time | Bronze |
 | The Relic Kill Isaac with Maggy | Bronze |
 | Guardian Angel Kill Satan with Maggy | Bronze |
 | Cain Hold 55 or more pennies at one time | Bronze |
 | The Coin Bag Kill Isaac with Cain | Bronze |
 | The Bomb Bag Kill Satan with Cain | Bronze |
 | Judas Kill Satan | Bronze |
 | The Guillotine Kill Isaac with Judas | Bronze |
 | Judas' Tongue Kill Satan with Judas | Bronze |
 | Eve Beat 2 levels in a row without picking up any hearts | Bronze |
 | Eve's Bird Foot Kill Isaac with Eve | Bronze |
 | The Razor Kill Satan with Eve | Bronze |
 | Samson Beat 2 levels in a row without taking damage | Bronze |
 | Bloody Lust Kill Isaac with Samson | Bronze |
 | Blood Rights Kill Satan with Samson | Bronze |
 | Azazel Make 3 deals with the devil in one run | Bronze |
 | The Satanic Bible Kill Isaac with Azazel | Bronze |
 | Daemon's Tail Kill Satan with Azazel | Bronze |
 | Lazarus Have 4 or more soul hearts at one time | Bronze |
 | Lazarus' Rags Kill Isaac with Lazarus | Bronze |
 | Broken Ankh Kill Satan with Lazarus | Bronze |
 | Eden Beat the Womb for the first time | Bronze |
 | A Blank Card Kill Isaac with Eden | Bronze |
 | The Book Of Secrets Kill Satan with Eden | Bronze |
 | Something from the future Beat the Basement 40 times | Bronze |
 | Something Cute Beat the Caves 30 times | Bronze |
 | Something sticky Beat the Depths 20 times | Bronze |
 | Basement Boy Beat the Basement/Cellar without taking damage | Bronze |
 | Spelunker Boy Beat the Caves/Catacombs without taking damage | Bronze |
 | Dark Boy Beat the Depths/Necropolis without taking damage | Bronze |
 | Mama's Boy Beat the Womb/Utero without taking damage | Bronze |
 | Dead Boy Beat the Chest or Dark Room without taking damage | Bronze |
 | Challenges Beat all 20 Challenges | Bronze |
 | Boss Rush Beat the Boss Rush |  Silver |
 | Dark Room Beat the Dark Room | Bronze |
 | The Chest Beat the Chest | Bronze |
 | Lost Poster Beat the Dark Room with Isaac | Bronze |
 | Little Baggy Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball | Bronze |
 | The Womb Kill Mom | Bronze |
 | The Halo Kill Mom using the Bible | Bronze |
 | Transcendence Kill Mom's Heart 3 times | Bronze |
 | Everything Is Terrible Kill Mom's Heart 5 times | Bronze |
 | A Quarter Kill Mom's Heart 8 times | Bronze |
 | A Fetus In A Jar Kill Mom's Heart 9 times | Bronze |
 | Blue Baby Kill Mom's Heart 10 times | Bronze |
 | It Lives Kill Mom's Heart 11 times | Bronze |
 | Forget Me Now Kill Satan with ??? | Bronze |
 | The Book Of Sin Kill all 7 sins | Bronze |
 | The Polaroid Beat Cathedral 5 times | Bronze |
 | The Negative Beat Sheol 5 times | Bronze |
 | Golden God You are the best! | Silver |
 | Platinum God Collect all items and unlock all secrets and endings |  Gold |
 | The Lost Finish the game's final secret | Bronze |
 | Real Platinum God 100% the game | Gold |
 | Lilith Beat Greed Mode with Azazel | Bronze |
 | Cambion Conception Kill ??? with Lilith | Bronze |
 | Succubus Kill The Lamb with Lilith | Bronze |
 | Keeper Donate 1000 coins in Greed Mode | Silver |
 | Deep Pockets Kill ??? with Keeper | Bronze |
 | Karma Kill The Lamb with Keeper | Bronze |
 | 1001% Collect all items and unlock all secrets | Gold |
 | Void Kill Delirium with Apollyon | Bronze |
 | Black Rune Beat Greedier Mode with Apollyon | Bronze |
 | Apollyon Baby Complete all hard mode marks with Apollyon | Silver |
 | New Area Kill Hush for the first time | Bronze |
 | Delirious Kill Delirium for the first time | Bronze |
 | RERUN Beat 3 victory laps in one run | Bronze |
 | 1000000% Just Stop! | Gold |
 | A Secret Exit Complete ??? 3 times | Bronze |
 | Bethany Beat Hard mode as Lazarus without losing a life | Bronze |
 | Jacob & Esau You are just like your father... | Bronze |
 | Red Key The other side is calling... | Bronze |
 | Mega Mush Beat everything in Hard Mode as every character | Bronze |
 | Death Certificate . . . | Silver |
 | Dead God ∞% | Gold |
