| icon | info | gamerscore |
|---|---|---|
 | Let's Rock! Complete the game on Human mode. | 10 |
 | Showtime! Complete the game on Devil Hunter mode. | 10 |
 | Doing Daddy Proud Complete the game on Son of Sparda mode. | 10 |
 | Dance with the Devil Complete the game on Dante Must Die mode. | 60 |
 | Stairway to Heaven Complete the game on Heaven or Hell mode. | 60 |
 | Highway to Hell Complete the game on Hell and Hell mode. | 100 |
 | Fall from Grace Clear the Prologue Mission. | 10 |
 | Protect the People Defeat all enemies in Mission 01. | 10 |
 | Where the Red Orbs Grow Collected Red Orbs from an unexpected spot in Mission 02. | 10 |
 | Reunion Clear Mission 03. | 10 |
 | Backroad Destroy a certain wall in Mission 04. | 10 |
 | Break a Leg Fend off a menace from above in Mission 05. | 10 |
 | End of the Line Clear Mission 06. | 10 |
 | Share the Pain Clear Mission 07 with both Nero and V. | 10 |
 | Light in the Darkness Clear Mission 08. | 10 |
 | Eagle-Eyed Destroy a certain wall in Mission 09. | 10 |
 | This Ain't Over Clear Mission 10. | 10 |
 | Don't Mess with the Best Use proper timing to get a leg up in a close-quarters battle against the boss in Mission 11. | 10 |
 | The Qliphoth Clear Mission 12. | 10 |
 | Each In His Own Way Clear Mission 13 with Nero, V, and Dante. | 10 |
 | Gotta Hurry Clear Mission 14. | 10 |
 | Slick Moves Proceed with caution and avoid unneeded damage in Mission 15. | 10 |
 | Obedience Training Go on the offensive without relying on brute force in the Mission 16 boss battle. | 10 |
 | Back to Life Clear Mission 17. | 10 |
 | Man on a Mission Clear Mission 18. | 10 |
 | Battle for the Ages Clear Missions 19 and 20 without using continues (any difficulty except Heaven or Hell). | 10 |
 | Not Too Shabby Perform a Stylish Rank S combo. | 10 |
 | Steppin' up the Style Perform a Stylish Rank SS combo. | 10 |
 | Seriously Stylish Slaying! Perform a Stylish Rank SSS combo. | 10 |
 | Secrets Exposed Clear all secret missions. | 60 |
 | The Quick and the Dead Defeat 5 enemies in 1 second. | 10 |
 | Well I'll Be Damned Wield overwhelming power to exact an unexpected conclusion. | 100 |
 | Hell of a Hunter Clear all missions with S rank. | 60 |
 | Worthy of Legend Clear all missions with S rank on all difficulties except Heaven or Hell. | 100 |
 | I Believe I Can Fly Rack up a total of 60 minutes in the air by jumping or other means. | 10 |
 | Nothing's Impossible Acquire all of Nero's skills. | 10 |
 | Be the Legend Acquire all of Dante's skills. | 10 |
 | Demon Breeder Acquire all of V's skills. | 10 |
 | Physical Perfection Upgrade your vitality gauge to max. | 10 |
 | The Devil's Own Upgrade your Devil Trigger Gauge to max. | 10 |
 | A New Job Accept a new job from Morrison after the Red Grave incident. | 10 |
 | Jackpot! Collect more than 1,000,000 Red Orbs total. | 60 |
 | Demon Destroyer Defeat 1,000 enemies total. | 10 |
 | Rearm and Repeat Collect more than 100 Devil Breakers during missions. | 10 |
 | Dante The Gambler Use more than 500,000 Red Orbs total with Dr. Faust. | 10 |
 | Who Needs Weapons Anyway? Clear Mission 11 without equipping a weapon set for Dante (any difficulty except Heaven or Hell). | 10 |
 | Unarmed and Dangerous Beat Mission 07 without any starting Devil Breakers equipped (any difficulty except Heaven or Hell). | 10 |
 | Pet Protection Clear Mission 05 without V's demons getting stalemated (any difficulty except Heaven or Hell). | 10 |
 | Slam Dunk Clear the Bloody Palace with Nero. | 60 |
 | Too Easy Clear the Bloody Palace with Dante. | 60 |
 | Rest in Peace Clear the Bloody Palace with V. | 60 |
 | Sibling Rivalry Clear all missions as Vergil. | 10 |
 | Concentrated Strength Acquire all of Vergil's skills. | 10 |
 | Heart of a Swordsman Clear Mission 19 as Vergil without using any weapons other than Yamato. (Heaven or Hell excluded) | 10 |
 | This is Power Clear the Bloody Palace as Vergil. | 60 |
