| icon | info | gamerscore |
|---|---|---|
 | Novice Beat the game on Novice difficulty or higher | 15 |
 | Calico Visit Calico for the first time | 15 |
 | Adapt or Die Defeat the Bruch | 30 |
 | Ticks and Leeches Defeat The Parasiter | 30 |
 | Drop of Blood Defeat William Rentier | 30 |
 | Ancient Blood Defeat Felicity D'Abano | 85 |
 | Spark of Hope Activate the Supercharged Mode for the first time | 15 |
 | Adept Beat the game on Normal difficulty or higher | 30 |
 | Expert Beat the game on Hard difficulty or higher | 85 |
 | Weird West Superhero Beat the game on Evil difficulty | 100 |
 | Boys'n'Toys Have all Weapon Upgrades activated at the same time | 30 |
 | Pew Pew Die Kill at least 30 enemies with each electrically-augmented firearm | 15 |
 | Field Agent Find all hidden perks | 15 |
 | Chest Nuts Pick up all cash on all missions | 15 |
 | Weren't You Listening? Defeat the Bruch on Evil difficulty | 30 |
 | Minor Deity Defeat The Parasiter on Evil difficulty | 30 |
 | Then You Died Defeat William Rentier on Evil difficulty | 30 |
 | Monsterball Cannonball enemies 50 times | 15 |
 | Slam Champion Slam enemies 100 times | 15 |
 | Pointless Violence Perform 15 finishers | 15 |
 | In the Feels Hit 45 weakspots | 15 |
 | E-Rodeo Kill 20 enemies using the E-Combo | 15 |
 | Bleed You Out Defeat the Bruch without letting it heal. | 70 |
 | Bio Friendly Defeat The Parasiter without killing any of the minions | 70 |
 | Father's Day Defeat William Rentier in less than 6 minutes | 70 |
 | Best the Beast Defeat Felicity D'Abano without using the HP dispenser | 70 |
 | Mighty Mitten Kill 10 enemies in a row using only Gauntlet after obtaining the Revolver | 15 |
 | Chewing Volts Use 15 Energy charges | 15 |
 | Sever Forever Tear off 100 limbs from enemies | 15 |
