| icon | info | gamerscore |
|---|---|---|
| Another Piece of Cake Beat The Doctor Who Cloned Me campaign on Easy Difficulty | 20 | |
| Let's Rock Out Beat The Doctor Who Cloned Me campaign on Normal Difficulty | 30 | |
| Bloody Red Rover Kill 30 enemies with the moon rover | 10 | |
| Bubble Buster Kill 10 expanded enemies with melee attacks | 10 | |
| Heart to Heart Finish Doctor Proton | 20 | |
| Threesome Kill 3 enemies within 3 seconds with the Impregnader | 10 | |
| Sticky Bomb Like You! Put a Trip Mine on a live alien | 10 | |
| Party Animal Drink all of the beers in the strip club | 10 | |
| Downtown Barrel Beatdown Kill 10 aliens with tossed objects | 15 | |
| Special Thanks Watch the credits all the way through | 5 | |
| Gunslinger Carry the gold pistol through the whole SP campaign | 50 | |
| Piece of Cake Complete the SP campaign on Easy Difficulty | 20 | |
| Let's Rock Complete the SP campaign on Normal Difficulty | 30 | |
| Beating the One-Eyed Worm Defeat the Energy Leech | 35 | |
| Octacide Defeat the Octaking | 25 | |
| Fork the Pork Kill 6 aliens with the forklift | 10 | |
| I Need a Date Look at every page of a calendar | 5 | |
| Freeze Well! Kill 15 frozen aliens | 20 | |
| Dead Useful Kill 10 aliens with environmental explosives | 15 | |
| A Good Dam Fight Defeat the Battlelord on the Hoover Dam | 25 | |
| He's Got a Hologram! Use a Holoduke in SP | 5 | |
| Road Rage Kill 15 aliens with the monster truck | 20 | |
| On the Noggin Kill 30 aliens with headshots | 25 | |
| Lots of Whacking Win a game of Alien Abortion in the strip club | 25 | |
| Not Bad for a Human Defeat the Alien Queen | 40 | |
| Noms Eat 10 pieces of food during the SP campaign | 10 | |
| Turd Burglar Find and steal a piece of poo | 10 | |
| Trapper Kill 10 aliens with Trip Mines | 20 | |
| I Need a Towel Get hit by 10 Pregnator bombs | 10 | |
| FBT Get knocked down 10 times | 10 | |
| Hippy-Stomper Foot stomp 12 aliens | 20 | |
| Nuclear Devastation Kill 250 aliens | 50 | |
| Pit Champion Defeat the Battlelord in Las Vegas | 25 | |
| Substance Abuser Drink beer while on steroids or vice versa in SP | 10 | |
| Judge, Jury, Executioner Execute 20 aliens | 20 | |
| Juiced Take steroids in SP | 5 | |
| Annihilation Kill 100 aliens | 40 | |
| Baron von Nukem Shoot down 20 alien fighters | 20 | |
| Natural Disaster 3x Kill 3 aliens at once | 10 | |
| Big Guns, Big Ships Blow up 5 enemy gunships or dropships | 10 | |
| Extermination Kill 50 aliens | 25 | |
| Flagon of Chuckles Drink a beer in SP | 5 | |
| Nobody Likes a Whiner Knock out the talent at the talk show | 5 | |
| One-Eyed Freak Defeat the Cycloid | 10 | |
| Sunday, Black Sunday Shoot down the blimp above the stadium | 5 | |
| Drawrings Doodle something on the whiteboard in SP | 10 | |
| Duke Angry, Duke Smash! Kill 15 aliens with melee attacks while on steroids | 20 | |
| Bucket Head Find all 3 helmets in the SP campaign | 30 | |
| Companion Barrel Unlock the secret closet at the end of the Forkstop | 10 | |
| Pescaphobe Kill all the catfish in the underwater level | 10 | |
| Air-Duke Win air hockey with a score of 7-0 in the strip club | 30 | |
| Balls of Steel Earn a 1,000,000 pinball score in SP | 25 |
